| Barbicambarus cornutus Faxon, 1884 | Bottle brush crayfish |
| Barbicambarus simmonsi Taylor & Sch..., 2010 | Tennessee Bottlebrush Crayfish |
| Cambarellus (Dirigicambarus) shufeldtii Faxon, 1884 | Cajun dwarf crayfish |
| Cambarellus (Pandicambarus) puer Hobbs, 1941 | Swamp dwarf crayfish |
| Cambarus (Aviticambarus) hamulatus Cope, 1881 | Prickly cave crayfish |
| Cambarus (Cambarus) angularis Hobbs & R. W..., 1994 | Angled Crayfish |
| Cambarus (Cambarus) bartonii Fabricius, 1798 | Appalachian brook crayfish |
| Cambarus (Cambarus) carinirostris Hay, 1914 | Rock crawfish |
| Cambarus (Cambarus) eeseeohensis Thoma, 2005 | Grandfather Mountain Crayfish |
| Cambarus (Cambarus) howardi Hobbs & Hall, 1969 | Chattahoochee crayfish |
| Cambarus (Depressicambarus) cymatilis Hobbs, 1970 | Conasauga Blue Burrower |
| Cambarus (Depressicambarus) deweesae R. W. Boucha..., 1979 | Valley flame crayfish |
| Cambarus (Depressicambarus) graysoni Faxon, 1914 | Two-spot crayfish |
| Cambarus (Depressicambarus) halli Hobbs, 1968 | Slackwater Crayfish |
| Cambarus (Depressicambarus) latimanus Le Conte, 1856 | Variable Crayfish |
| Cambarus (Depressicambarus) obstipus Hall, 1959 | Sloped Crayfish |
| Cambarus (Depressicambarus) sphenoides Hobbs, 1968 | Triangleclaw Crayfish |
| Cambarus (Depressicambarus) striatus Hay, 1902 | Ambiguous Crayfish |
| Cambarus (Erebicambarus) maculatus Hobbs & Pfli..., 1988 | Freckled crayfish |
| Cambarus (Erebicambarus) rusticiformis Rhoades, 1944 | Depression crayfish |
| Cambarus (Erebicambarus) tenebrosus Hay, 1902 | Cavespring crayfish |
| Cambarus (Exilicambarus) cracens R. W. Boucha..., 1976 | Slenderclaw Crayfish |
| Cambarus (Glareocola) brachydactylus Hobbs, 1953 | Shortfinger Crayfish |
| Cambarus (Glareocola) friaufi Hobbs, 1953 | Hairy crayfish |
| Cambarus (Glareocola) williami R. W. Boucha..., 1995 | Big Sandy crayfish |
| Cambarus (Hiaticambarus) girardianus Faxon, 1884 | Tanback Crayfish |
| Cambarus (Hiaticambarus) longirostris Faxon, 1885 | Longnose Crayfish |
| Cambarus (Hiaticambarus) longulus Girard, 1852 | Atlantic Slope Crayfish |
| Cambarus (Hiaticambarus) manningi Hobbs, 1981 | Greensaddle Crayfish |
| Cambarus (Jugicambarus) asperimanus Faxon, 1914 | Mitten Crayfish |
| Cambarus (Jugicambarus) bouchardi Hobbs, 1970 | Big South Fork crayfish |
| Cambarus (Jugicambarus) carolinus Erichson, 1846 | Red Burrowing Crayfish |
| Cambarus (Jugicambarus) clivosus Taylor, Souc..., 2006 | Short Mountain Crayfish |
| Cambarus (Jugicambarus) conasaugaensis Hobbs & Hobb..., 1962 | Mountain Crayfish |
| Cambarus (Jugicambarus) crinipes R. W. Bouchard, 1973 | Hairyfoot Crayfish |
| Cambarus (Jugicambarus) cryptodytes Hobbs, 1941 | Apalachicola cave crayfish |
| Cambarus (Jugicambarus) distans Rhoades, 1944 | Boxclaw crawfish |
| Cambarus (Jugicambarus) dubius Faxon, 1884 | Upland burrowing crayfish |
| Cambarus (Jugicambarus) gentryi Hobbs, 1970 | Linear Cobalt Crayfish |
| Cambarus (Jugicambarus) jezerinaci Thoma, 2000 | Spiny Scale Crayfish |
| Cambarus (Jugicambarus) nodosus R. W. Boucha..., 1976 | Knotty Burrowing Crayfish |
| Cambarus (Jugicambarus) obeyensis Hobbs & Shoup, 1947 | Obey crayfish |
| Cambarus (Jugicambarus) parvoculus Hobbs & Shoup, 1947 | Mountain midget crayfish |
| Cambarus (Jugicambarus) tuckasegee Cooper & Sch..., 2002 | Tuckasegee Stream Crayfish |
| Cambarus (Lacunicambarus) diogenes Girard, 1852 | Chimney crayfish |
| Cambarus (Lacunicambarus) ludovicianus Faxon, 1884 | Painted devil crayfish |
| Cambarus (Puncticambarus) acuminatus Faxon, 1884 | Acuminate Crayfish |
| Cambarus (Puncticambarus) buntingi R. W. Bouchard, 1973 | Bunting crayfish |
| Cambarus (Puncticambarus) chaugaensis Prins & Hobbs, 1972 | Chauga crayfish |
| Cambarus (Puncticambarus) coosae Hobbs, 1981 | Coosa Crayfish |
| Cambarus (Puncticambarus) cumberlandensis Hobbs & R. W..., 1973 | Cumberland crayfish |
| Cambarus (Puncticambarus) extraneus Hagen, 1870 | Chickamauga crayfish |
| Cambarus (Puncticambarus) georgiae Hobbs, 1981 | Little Tennessee crayfish |
| Cambarus (Puncticambarus) hiwasseensis Hobbs, 1981 | Hiwassee crayfish |
| Cambarus (Puncticambarus) hobbsorum J. E. Cooper, 2001 | Rocky River crayfish |
| Cambarus (Puncticambarus) johni Cooper, 2006 | Carolina Foothills Crayfish |
| Cambarus (Puncticambarus) robustus Girard, 1852 | Big water crayfish |
| Cambarus (Puncticambarus) veteranus Faxon, 1914 | Big Sandy crayfish |
| Cambarus (Tubericambarus) acanthura Hobbs, 1981 | Thornytail Crayfish |
| Cambarus (Tubericambarus) stockeri Thoma, 2011 | Cocoa Crayfish |
| Cambarus (Tubericambarus) thomai Jezerinac, 1993 | Little brown mudbug |
| Cambarus (Veticambarus) pristinus Hobbs, 1965 | Pristine crayfish |
| Cambarus appalachiensis Loughman, We..., 2017 | Conhaway Crayfish |
| Cambarus cahni Rhoades, 1944 | |
| Cambarus hazardi Loughman, He..., 2017 | Brawny Crayfish |
| Cambarus polypilosus Loughman & W..., 2018 | Hillbilly hairy crayfish |
| Cambarus taylori Loughman, He..., 2017 | Cutshin Crayfish |
| Creaserinus hortoni Hobbs & Fitz..., 1970 | Hatchie burrowing crayfish |
| Fallicambarus (Creaserinus) fodiens Cottle, 1863 | Digger crayfish |
| Fallicambarus (Creaserinus) hedgpethi Hobbs, 1948 | |
| Fallicambarus (Creaserinus) hortoni Hobbs & Fitz..., 1970 | Hatchie burrowing crayfish |
| Faxonius juvenilis Hagen, 1870 | Kentucky River Crayfish |
| Faxonius taylori Schuster, 2008 | Crescent Crayfish |
| Faxonius yanahlindus Taylor, Rhod..., 2016 | Spinywrist Crayfish |
| Hoploparia tennesseensis ♰ Rathbun & Wade, 1926 | |
| Lacunicambarus chimera Glon & Thoma, 2019 | Crawzilla Crawdad |
| Lacunicambarus polychromatus Thoma, Jezer..., 2005 | Paintedhand Mudbug |
| Orconectes (Buannulifictus) palmeri Creaser, 1933 | Creole Painted Crayfish |
| Orconectes (Crockerinus) burri Taylor & Sabaj, 1998 | Blood River crayfish |
| Orconectes (Crockerinus) erichsonianus Faxon, 1898 | Reticulate crayfish |
| Orconectes (Crockerinus) propinquus Girard, 1852 | Northern clearwater crayfish |
| Orconectes (Crockerinus) shoupi Hobbs, 1948 | Nashville crayfish |
| Orconectes (Faxonius) wrighti Hobbs, 1948 | Hardin crayfish |
| Orconectes (Gremicambarus) alabamensis Faxon, 1884 | |
| Orconectes (Gremicambarus) causeyi Jester, 1967 | Western plains crayfish |
| Orconectes (Gremicambarus) compressus Faxon, 1884 | Slender crayfish |
| Orconectes (Gremicambarus) virilis Hagen, 1870 | Common Crawfish |
| Orconectes (Orconectes) australis Rhoades, 1941 | Appalachian Cave Crayfish |
| Orconectes (Orconectes) barri Buhay & Cran..., 2008 | Cumberland Plateau Cave Crayfish |
| Orconectes (Orconectes) incomptus Hobbs & Barr, 1972 | Tennessee cave crayfish |
| Orconectes (Orconectes) pagei Taylor & Sabaj, 1997 | Mottled crayfish |
| Orconectes (Orconectes) pellucidus Tellkampf, 1844 | Mammoth Cave crayfish |
| Orconectes (Procericambarus) barrenensis Rhoades, 1944 | Barren River crayfish |
| Orconectes (Procericambarus) cristavarius Taylor, 2000 | Spiny stream crayfish |
| Orconectes (Procericambarus) durelli R. W. Boucha..., 1995 | Saddle crayfish |
| Orconectes (Procericambarus) forceps Faxon, 1884 | Surgeon crayfish |
| Orconectes (Procericambarus) mirus Ortmann, 1931 | Wonderful crayfish |
| Orconectes (Procericambarus) placidus Hagen, 1870 | Bigclaw crayfish |
| Orconectes (Procericambarus) putnami Faxon, 1884 | Phallic crayfish |
| Orconectes (Procericambarus) ronaldi Taylor, 2000 | Mild River Crayfish |
| Orconectes (Procericambarus) rusticus Girard, 1852 | Rusty crayfish |
| Orconectes (Procericambarus) spinosus Bundy, 1877 | Coona River spiny crayfish |
| Orconectes (Rhoadesius) kentuckiensis Rhoades, 1944 | Kentucky crayfish |
| Orconectes (Tragulicambarus) lancifer Hagen, 1870 | Shrimp crayfish |
| Orconectes (Trisellescens) alabamensis Faxon, 1884 | Alabama crayfish |
| Orconectes (Trisellescens) cooperi Cooper & Hobbs, 1980 | Flint River crayfish |
| Orconectes (Trisellescens) etnieri Bouchard & B..., 1976 | Ets crayfish |
| Orconectes (Trisellescens) immunis Hagen, 1870 | Calico crayfish |
| Orconectes (Trisellescens) rhoadesi Hobbs, 1949 | Fishhook crayfish |
| Orconectes (Trisellescens) taylori Schuster, 2008 | Crescent crayfish |
| Orconectes (Trisellescens) validus Faxon, 1914 | Powerful crayfish |
| Procambarus (Acucauda) fitzpatricki Hobbs, 1971 | Spiny-tail Crayfish |
| Procambarus (Girardiella) liberorum Fitzpatrick, 1978 | Osage burrowing crayfish |
| Procambarus (Hagenides) caritus Hobbs, 1981 | Poor Crayfish |
| Procambarus (Hagenides) talpoides Hobbs, 1981 | Mole Crayfish |
| Procambarus (Leconticambarus) hubbelli Hobbs, 1940 | Jackknife Crayfish |
| Procambarus (Ortmannicus) acutus Girard, 1852 | White river crawfish |
| Procambarus (Ortmannicus) fallax Hagen, 1870 | Deceitful Crayfish |
| Procambarus (Ortmannicus) hayi Faxon, 1884 | Straightedge Crayfish |
| Procambarus (Ortmannicus) lophotus Hobbs & Walton, 1960 | Mane Crayfish |
| Procambarus (Ortmannicus) mancus Hobbs & Walton, 1957 | Lame Crayfish |
| Procambarus (Ortmannicus) viaeviridis Faxon, 1914 | Vernal crayfish |
| Procambarus (Pennides) ablusus Penn, 1963 | Hatchie River Crayfish |
| Procambarus (Pennides) dupratzi Penn, 1953 | Southwestern Creek Crayfish |
| Procambarus (Pennides) elegans Hobbs, 1969 | Elegant Creek Crayfish |
| Procambarus (Pennides) spiculifer LeConte, 1856 | White Tubercled Crayfish |
| Procambarus (Pennides) vioscai Penn, 1946 | Burnham's blackberry |
| Procambarus (Scapulicambarus) clarkii Girard, 1852 | American crayfish |
| Procambarus (Scapulicambarus) paeninsulanus Faxon, 1914 | Peninsula Crayfish |
