| Cambarellus (Dirigicambarus) shufeldtii Faxon, 1884 | Cajun dwarf crayfish |
| Cambarus (Cambarus) bartonii Fabricius, 1798 | Appalachian brook crayfish |
| Cambarus (Cambarus) howardi Hobbs & Hall, 1969 | Chattahoochee crayfish |
| Cambarus (Depressicambarus) cymatilis Hobbs, 1970 | Conasauga Blue Burrower |
| Cambarus (Depressicambarus) doughertyensis Cooper & Ske..., 2003 | Dougherty Burrowing Crayfish |
| Cambarus (Depressicambarus) englishi Hobbs & Hall, 1972 | Tallapoosa Crayfish |
| Cambarus (Depressicambarus) halli Hobbs, 1968 | Slackwater Crayfish |
| Cambarus (Depressicambarus) harti Hobbs, 1981 | Piedmont blue burrower |
| Cambarus (Depressicambarus) latimanus Le Conte, 1856 | Variable Crayfish |
| Cambarus (Depressicambarus) reflexus Hobbs, 1981 | Pine Savannah Crayfish |
| Cambarus (Depressicambarus) striatus Hay, 1902 | Ambiguous Crayfish |
| Cambarus (Depressicambarus) strigosus Hobbs, 1981 | Lean Crayfish |
| Cambarus (Depressicambarus) truncatus Hobbs, 1981 | Oconee burrowing crayfish |
| Cambarus (Hiaticambarus) coosawattae Hobbs, 1981 | Coosawattae crayfish |
| Cambarus (Hiaticambarus) fasciatus Hobbs, 1981 | Etowah crayfish |
| Cambarus (Hiaticambarus) girardianus Faxon, 1884 | Tanback Crayfish |
| Cambarus (Hiaticambarus) longirostris Faxon, 1885 | Longnose Crayfish |
| Cambarus (Hiaticambarus) longulus Girard, 1852 | Atlantic Slope Crayfish |
| Cambarus (Hiaticambarus) manningi Hobbs, 1981 | Greensaddle Crayfish |
| Cambarus (Hiaticambarus) speciosus Hobbs, 1981 | Beautiful Crayfish |
| Cambarus (Jugicambarus) asperimanus Faxon, 1914 | Mitten Crayfish |
| Cambarus (Jugicambarus) carolinus Erichson, 1846 | Red Burrowing Crayfish |
| Cambarus (Jugicambarus) conasaugaensis Hobbs & Hobb..., 1962 | Mountain Crayfish |
| Cambarus (Jugicambarus) cryptodytes Hobbs, 1941 | Apalachicola cave crayfish |
| Cambarus (Jugicambarus) distans Rhoades, 1944 | Boxclaw crawfish |
| Cambarus (Jugicambarus) nodosus R. W. Boucha..., 1976 | Knotty Burrowing Crayfish |
| Cambarus (Jugicambarus) parvoculus Hobbs & Shoup, 1947 | Mountain midget crayfish |
| Cambarus (Jugicambarus) unestami Hobbs & Hall, 1969 | Blackbarred Crayfish |
| Cambarus (Lacunicambarus) diogenes Girard, 1852 | Chimney crayfish |
| Cambarus (Puncticambarus) acuminatus Faxon, 1884 | Acuminate Crayfish |
| Cambarus (Puncticambarus) chaugaensis Prins & Hobbs, 1972 | Chauga crayfish |
| Cambarus (Puncticambarus) coosae Hobbs, 1981 | Coosa Crayfish |
| Cambarus (Puncticambarus) extraneus Hagen, 1870 | Chickamauga crayfish |
| Cambarus (Puncticambarus) georgiae Hobbs, 1981 | Little Tennessee crayfish |
| Cambarus (Puncticambarus) hiwasseensis Hobbs, 1981 | Hiwassee crayfish |
| Cambarus (Puncticambarus) parrishi Hobbs, 1981 | Hiwassee headwater crayfish |
| Cambarus (Puncticambarus) reburrus Prins, 1968 | French Broad crayfish |
| Cambarus (Puncticambarus) robustus Girard, 1852 | Big water crayfish |
| Cambarus (Puncticambarus) scotti Hobbs, 1981 | Chatooga crayfish |
| Cambarus (Tubericambarus) acanthura Hobbs, 1981 | Thornytail Crayfish |
| Cambarus (Tubericambarus) stockeri Thoma, 2011 | Cocoa Crayfish |
| Cambarus hiwasseenis | |
| Cambarus jordani Faxon, 1884 | |
| Distocambarus (Distocambarus) crockeri Hobbs and Ca..., 1983 | Piedmont Prairie Burrowing Crayfish |
| Distocambarus (Distocambarus) devexus Hobbs, 1981 | Broad River Burrowing Crayfish |
| Fallicambarus (Creaserinus) fodiens Cottle, 1863 | Digger crayfish |
| Fallicambarus (Creaserinus) hedgpethi Hobbs, 1948 | |
| Fallicambarus hiwasseensis | |
| Faxonella clypeata Hay, 1899 | Ditch fencing crayfish |
| Faxonius yanahlindus Taylor, Rhod..., 2016 | Spinywrist Crayfish |
| Lacunicambarus polychromatus Thoma, Jezer..., 2005 | Paintedhand Mudbug |
| Orconectes (Crockerinus) erichsonianus Faxon, 1898 | Reticulate crayfish |
| Orconectes (Gremicambarus) virilis Hagen, 1870 | Common Crawfish |
| Orconectes (Procericambarus) forceps Faxon, 1884 | Surgeon crayfish |
| Orconectes (Procericambarus) mirus Ortmann, 1931 | Wonderful crayfish |
| Orconectes (Procericambarus) placidus Hagen, 1870 | Bigclaw crayfish |
| Orconectes (Procericambarus) spinosus Bundy, 1877 | Coona River spiny crayfish |
| Orconectes (Tragulicambarus) lancifer Hagen, 1870 | Shrimp crayfish |
| Orconectes (Trisellescens) validus Faxon, 1914 | Powerful crayfish |
| Procambarus (Girardiella) hagenianus Faxon, 1884 | Egyptian Crayfish |
| Procambarus (Hagenides) advena LeConte, 1856 | Vidalia Crayfish |
| Procambarus (Hagenides) caritus Hobbs, 1981 | Poor Crayfish |
| Procambarus (Hagenides) pygmaeus Hobbs, 1942 | Christmas tree crayfish |
| Procambarus (Hagenides) talpoides Hobbs, 1981 | Mole Crayfish |
| Procambarus (Hagenides) truculentus Hobbs, 1954 | Bog Crayfish |
| Procambarus (Leconticambarus) alleni Faxon, 1884 | Blue Cray Fish |
| Procambarus (Leconticambarus) barbatus Faxon, 1890 | Wandering Crayfish |
| Procambarus (Leconticambarus) pubischelae Hobbs, 1942 | Bloodroot |
| Procambarus (Ortmannicus) acutissimus Girard, 1852 | Sharpnose Crayfish |
| Procambarus (Ortmannicus) acutus Girard, 1852 | White river crawfish |
| Procambarus (Ortmannicus) angustatus LeConte, 1856 | Sandhills crayfish |
| Procambarus (Ortmannicus) blandingii Harlan, 1830 | Santee Crayfish |
| Procambarus (Ortmannicus) enoplosternum Hobbs, 1947 | Black Mottled Crayfish |
| Procambarus (Ortmannicus) epicyrtus Hobbs, 1958 | Humpback Crayfish |
| Procambarus (Ortmannicus) fallax Hagen, 1870 | Deceitful Crayfish |
| Procambarus (Ortmannicus) hayi Faxon, 1884 | Straightedge Crayfish |
| Procambarus (Ortmannicus) lecontei Hagen, 1870 | Mobile crayfish |
| Procambarus (Ortmannicus) litosternum Hobbs, 1947 | Blackwater Crayfish |
| Procambarus (Ortmannicus) lophotus Hobbs & Walton, 1960 | Mane Crayfish |
| Procambarus (Ortmannicus) lunzi Hobbs, 1940 | Hummock Crayfish |
| Procambarus (Ortmannicus) plumimanus Hobbs & Walton, 1958 | Croatan Crayfish |
| Procambarus (Ortmannicus) pubescens Faxon, 1884 | Brushnose Crayfish |
| Procambarus (Ortmannicus) seminolae Hobbs, 1942 | Seminole crayfish |
| Procambarus (Ortmannicus) verrucosus Hobbs, 1952 | Grainy Crayfish |
| Procambarus (Pennides) gibbus Hobbs, 1969 | Muckalee Crayfish |
| Procambarus (Pennides) petersi Hobbs, 1981 | Ogeechee Crayfish |
| Procambarus (Pennides) raneyi Hobbs, 1953 | Disjunct Crayfish |
| Procambarus (Pennides) spiculifer LeConte, 1856 | White Tubercled Crayfish |
| Procambarus (Pennides) versutus Hagen, 1870 | Sly Crayfish |
| Procambarus (Scapulicambarus) clarkii Girard, 1852 | American crayfish |
| Procambarus (Scapulicambarus) howellae Hobbs, 1952 | Ornate Crayfish |
| Procambarus (Scapulicambarus) paeninsulanus Faxon, 1914 | Peninsula Crayfish |
| Procambarus (Scapulicambarus) troglodytes LeConte, 1856 | Eastern Red Swamp Crawfish |
| Procambarus deuexus | |
